Collagen type VI is the antigen recognized by the ER-TR7 antibody

Alvise Schiavinato; Matthias Przyklenk; Birgit Kobbe; Mats Paulsson; Raimund Wagener

doi:10.1002/eji.202149263

Collagen type VI is the antigen recognized by the ER-TR7 antibody

Eur J Immunol. 2021 Sep;51(9):2345-2347. doi: 10.1002/eji.202149263. Epub 2021 Jul 11.

Authors

Alvise Schiavinato^{1

2}, Matthias Przyklenk¹, Birgit Kobbe¹, Mats Paulsson^{1

3

4}, Raimund Wagener¹

Affiliations

¹ Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany.
² Istituto Di Patologia Clinica, Azienda Sanitaria Universitaria Integrata di Udine (ASUID), Udine, Italy.
³ Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
⁴ Center for Musculoskeletal Biomechanics (CCMB), Medical Faculty, University of Cologne, Cologne, Germany.

PMID: 34180542
DOI: 10.1002/eji.202149263

Abstract

The monoclonal antibody ER-TR7 was used in a great number of studies for detecting reticular fibroblasts and the ECM of lymphoid and non-lymphoid organs even if the protein recognized by the ER-TR7 antibody was not known. We have now identified native collagen VI microfibrils as its tissue antigen.

Keywords: ER-TR7; collagen VI.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Monoclonal / immunology*
Antigens / immunology
Collagen Type VI / immunology*
Mice
Spleen / cytology
Spleen / immunology
Stromal Cells / immunology*
Thymus Gland / cytology
Thymus Gland / immunology

Substances

Antibodies, Monoclonal
Antigens
Collagen Type VI