Facile Approach to C-Glucosides by Using a Protecting-Group-Free Hiyama Cross-Coupling Reaction: High-Yielding Dapagliflozin Synthesis

Karolína Vaňková; Michal Rahm; Jan Choutka; Radek Pohl; Kamil Parkan

doi:10.1002/chem.202101995

Facile Approach to C-Glucosides by Using a Protecting-Group-Free Hiyama Cross-Coupling Reaction: High-Yielding Dapagliflozin Synthesis

Chemistry. 2021 Jul 21;27(41):10488. doi: 10.1002/chem.202101995. Epub 2021 Jun 27.

Authors

Karolína Vaňková¹, Michal Rahm¹, Jan Choutka¹, Radek Pohl², Kamil Parkan¹

Affiliations

¹ Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28, Prague 6, Czech Republic.
² Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences & IOCB Research Centre, Flemingovo nám. 2, 166 10, Prague, Czech Republic.

PMID: 34180093
DOI: 10.1002/chem.202101995

Abstract

Invited for the cover of this issue is Kamil Parkan and co-workers at University of Chemistry and Technology and Institute of Organic Chemistry and Biochemistry, Prague. The cover graphic depicts a schematic representation of the assembly of aryl-C-glycosides based on a protecting-group-free Hiyama reaction. Read the full text of the article at 10.1002/chem.202101052.

MeSH terms

Benzhydryl Compounds*
Chemistry, Organic
Glucosides*
Glycosides
Humans

Substances

Benzhydryl Compounds
Glucosides
Glycosides
dapagliflozin