Biaryl Formation via Base-Promoted Direct Coupling Reactions of Arenes with Aryl Halides

Muhammad Asif Iqbal; Le Lu; Hina Mehmood; Ruimao Hua

doi:10.1021/acsomega.1c01736

Biaryl Formation via Base-Promoted Direct Coupling Reactions of Arenes with Aryl Halides

ACS Omega. 2021 Jun 9;6(24):15981-15987. doi: 10.1021/acsomega.1c01736. eCollection 2021 Jun 22.

Authors

Muhammad Asif Iqbal¹, Le Lu¹, Hina Mehmood¹, Ruimao Hua¹

Affiliation

¹ Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China.

Abstract

In the absence of ligand, Cs₂CO₃-promoted cross-coupling reaction of arenes with cyano-/nitro-substituted aryl halides in DMSO affording biaryls is reported. The cyano/nitro group in biaryls is useful and convenient for further transformation. The formation of dibenzofurans resulting from the reactions between arenes and 1-bromo-2-iodobenzene is also reported. On the basis of control experiments and theoretical studies, a radical mechanism is proposed for the formation of biaryls.