Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword

Ding Yao; Yang GangYi; Wu QiNan

doi:10.1016/j.gendis.2020.03.003

Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword

Genes Dis. 2020 Mar 19;8(4):438-447. doi: 10.1016/j.gendis.2020.03.003. eCollection 2021 Jul.

Authors

Ding Yao¹, Yang GangYi², Wu QiNan¹

Affiliations

¹ Endocrinology and Nephrology Department, Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer Hospital, Chongqing, 400030, PR China.
² Endocrinology Department, The Second Affiliated Hospital of the Chongqing Medical University, Chongqing, 400010, PR China.

Abstract

Diabetes is an age-related disease, most of which is type 2 diabetes, and islet β cell dysfunction and insulin resistance are the main mechanisms of type 2 diabetes. Recent studies have revealed that autophagy plays an important role in maintaining the structure and function of islet beta cells and inhibiting insulin resistance and apoptosis induced by oxidative stress. In this review, we discussed the positive and negative effects of autophagy and its dysfunction on type 2 diabetes mellitus, which is the so-called double-edged sword, analysed its possible mechanism, and identified possible research hot spots.

Keywords: Apoptosis; Autophagic dysfunction; Insulin resistance; Islet beta cell dysfunction; Type 2 diabetes mellitus.

Publication types

Review