Nano-engineered screen-printed electrodes: A dynamic tool for detection of viruses

Mazhar Sher; Aroosha Faheem; Waseem Asghar; Stefano Cinti

doi:10.1016/j.trac.2021.116374

Nano-engineered screen-printed electrodes: A dynamic tool for detection of viruses

Trends Analyt Chem. 2021 Oct:143:116374. doi: 10.1016/j.trac.2021.116374. Epub 2021 Jun 21.

Authors

Mazhar Sher^{1

2}, Aroosha Faheem³, Waseem Asghar^{1

2

4}, Stefano Cinti^{5

6}

Affiliations

¹ Asghar-Lab, Micro and Nanotechnology in Medicine, College of Engineering and Computer Science, Boca Raton, FL 33431, USA.
² Department of Computer & Electrical Engineering and Computer Science, Florida Atlantic University, Boca Raton, FL 33431, USA.
³ State Key Laboratory of Agricultural Microbiology, College of Life Sciences and Technology, Huazhong Agricultural University, Wuhan 430070, China.
⁴ Department of Biological Sciences (Courtesy Appointment), Florida Atlantic University, Boca Raton, FL 33431, USA.
⁵ Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131, Naples, Italy.
⁶ BAT Center-Interuniversity Center for Studies on Bioinspired Agro-Environmental Technology, University of Napoli "Federico II", 80055 Naples, Italy.

Abstract

There is a growing interest in the development of portable, cost-effective, and easy-to-use biosensors for the rapid detection of diseases caused by infectious viruses: COVID-19 pandemic has highlighted the central role of diagnostics in response to global outbreaks. Among all the existing technologies, screen-printed electrodes (SPEs) represent a valuable technology for the detection of various viral pathogens. During the last five years, various nanomaterials have been utilized to modify SPEs to achieve convincing effects on the analytical performances of portable SPE-based diagnostics. Herein we would like to provide the readers a comprehensive investigation about the recent combination of SPEs and various nanomaterials for detecting viral pathogens. Manufacturing methods and features advances are critically discussed in the context of early-stage detection of diseases caused by HIV-1, HBV, HCV, Zika, Dengue, and Sars-CoV-2. A detailed table is reported to easily guide readers toward the "right" choice depending on the virus of interest.

Keywords: Immunoassays; Nanomaterials; SARS CoV-2; Screen-printed electrodes (SPEs); Viruses.

Publication types

Review