Hemodialysis acutely altered interferon-gamma release assay test result and immune cell profile

Denise Utami Putri; Chia-Ling Chen; Cheng-Hui Wang; Yuh-Mou Sue; Po-Chun Tseng; Chiou-Feng Lin; Ching-Wen Tsai; Yi-Jun Liu; Chih-Hsin Lee

doi:10.1016/j.jmii.2021.03.022

Hemodialysis acutely altered interferon-gamma release assay test result and immune cell profile

J Microbiol Immunol Infect. 2022 Apr;55(2):332-335. doi: 10.1016/j.jmii.2021.03.022. Epub 2021 Jun 11.

Authors

Denise Utami Putri¹, Chia-Ling Chen², Cheng-Hui Wang³, Yuh-Mou Sue⁴, Po-Chun Tseng⁵, Chiou-Feng Lin⁶, Ching-Wen Tsai⁷, Yi-Jun Liu⁸, Chih-Hsin Lee⁹

Affiliations

¹ Pulmonary Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address: 108336@w.tmu.edu.tw.
² Pulmonary Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: chialing66@tmu.edu.tw.
³ Pulmonary Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Laboratory Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan. Electronic address: 93059@w.tmu.edu.tw.
⁴ Division of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of Nephrology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address: sueym@tmu.edu.tw.
⁵ Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Immune Monitoring Core, Office of Research and Development, Taipei Medical University, Taipei, Taiwan. Electronic address: pctseng@tmu.edu.tw.
⁶ Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Immune Monitoring Core, Office of Research and Development, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: cflin2014@tmu.edu.tw.
⁷ Research Center of Biostatistics, College of Management, Taipei Medical University, Taipei, Taiwan. Electronic address: s7120570@tmu.edu.tw.
⁸ Pulmonary Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address: snoopy19901015@gmail.com.
⁹ Pulmonary Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: chleetw@tmu.edu.tw.

PMID: 34175241
DOI: 10.1016/j.jmii.2021.03.022

Abstract

Patients receiving hemodialysis (HD) are at risk of TB development. IGRA-positive patients showed significant decrease in quantitative IGRA result with alterations in CD3⁺CD4⁺CD45RO⁺, NK cell, and monocyte subsets immediately upon HD procedure. Our result suggested that the timing of IGRA testing is crucial in end-stage renal disease population.

Keywords: End stage renal disease; Hemodialysis; IGRA variability; Interferon gamma-release assay; Peripheral immune profile.

MeSH terms

Female
Humans
Interferon-gamma
Interferon-gamma Release Tests / methods
Kidney Failure, Chronic* / therapy
Latent Tuberculosis* / epidemiology
Male
Renal Dialysis / adverse effects
Tuberculin Test / methods

Substances

Interferon-gamma