Condition of Adrenergic Innervation Apparatus of the Thyroid Gland, Blood and Lymph Vessels, and Lymph Nodes during Correction of Hypothyrosis

Bull Exp Biol Med. 2021 May;171(2):281-285. doi: 10.1007/s10517-021-05212-5. Epub 2021 Jun 26.

Abstract

We used specific histochemical fluorescence-microscopic method of visualization of catecholamines to study adrenergic innervation of the thyroid gland tissue, blood vessels of the thyroid gland, cervical lymphatic vessel and lymph nodes in rats during correction of hypothyroidism with a bioactive formulation (Vozrozhdenie Plus balm with Potentilla alba L.). In experimental hypothyroidism, adrenergic innervation of the thyroid gland and the wall of the cervical lymph node, concentrated mainly along the arterial vessels and the cervical lymphatic vessel, retained its structural formations (plexuses and varicosities), but diffusion of catecholamines outside these formations was observed. Correction with the bioactive formulation restored of the contours of the nerve plexuses and varicosities and their brighter fluorescence in the thyroid gland and cervical lymphatic vessel and node. During correction of hypothyroidism with the bioactive formulation, reorganization of regional lymphatic vessels and nodes was more pronounced than reorganization of the thyroid gland.

Keywords: Potentilla alba L. extract; adrenergic nervous apparatus; correction of hypothyroidism; iodine; lymphatic vessels and nodes.

MeSH terms

  • Adrenergic Fibers / drug effects
  • Adrenergic Fibers / pathology
  • Adrenergic Fibers / ultrastructure
  • Animals
  • Blood Vessels / diagnostic imaging
  • Blood Vessels / drug effects
  • Blood Vessels / pathology
  • Hypothyroidism* / diagnostic imaging
  • Hypothyroidism* / drug therapy
  • Hypothyroidism* / pathology
  • Lymph Nodes / diagnostic imaging
  • Lymph Nodes / drug effects
  • Lymph Nodes / pathology*
  • Lymphatic Vessels / diagnostic imaging
  • Lymphatic Vessels / drug effects
  • Lymphatic Vessels / pathology*
  • Male
  • Microscopy, Fluorescence
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Potassium Iodide / pharmacology
  • Potassium Iodide / therapeutic use
  • Rats
  • Thyroid Gland / blood supply*
  • Thyroid Gland / diagnostic imaging
  • Thyroid Gland / drug effects
  • Thyroid Gland / innervation*
  • Thyroid Hormones / pharmacology
  • Thyroid Hormones / therapeutic use

Substances

  • Plant Extracts
  • Thyroid Hormones
  • Potassium Iodide