Development of the Verbal Autopsy Instrument for COVID-19 (VAIC)

J Gen Intern Med. 2021 Nov;36(11):3522-3529. doi: 10.1007/s11606-021-06842-1. Epub 2021 Jun 25.

Abstract

Background: Improving accuracy of identification of COVID-19-related deaths is essential to public health surveillance and research. The verbal autopsy, an established strategy involving an interview with a decedent's caregiver or witness using a semi-structured questionnaire, may improve accurate counting of COVID-19-related deaths.

Objective: To develop and pilot-test the Verbal Autopsy Instrument for COVID-19 (VAIC) and a death adjudication protocol using it.

Methods/key results: We used a multi-step process to design the VAIC and a protocol for its use. We developed a preliminary version of a verbal autopsy instrument specifically for COVID. We then pilot-tested this instrument by interviewing respondents about the deaths of 15 adults aged ≥65 during the initial COVID-19 surge in New York City. We modified it after the first 5 interviews. We then reviewed the VAIC and clinical information for the 15 deaths and developed a death adjudication process/algorithm to determine whether the underlying cause of death was definitely (40% of these pilot cases), probably (33%), possibly (13%), or unlikely/definitely not (13%) COVID-19-related. We noted differences between the adjudicated cause of death and a death certificate.

Conclusions: The VAIC and a death adjudication protocol using it may improve accuracy in identifying COVID-19-related deaths.

Keywords: COVID-19; mortality; verbal autopsy.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Autopsy
  • COVID-19*
  • Cause of Death
  • Humans
  • SARS-CoV-2
  • Surveys and Questionnaires