Abstract
The presence of IgG and IgM antibodies in the venous blood of 76 patients with confirmed COVID-19 infection was determined by ELISA using Russian test systems. Different levels of IgM antibodies to N-protein and receptor binding domain of the Spike protein (RBD) were revealed. The dynamics of IgG antibodies to the whole virion antigen and recombinant antigens showed high values on weeks 4-5 of the disease. The level of IgG antibodies to Nprotein remained low throughout the observation period. The characteristic dynamics of IgG measured using test systems with sorbed whole virion or recombinant spike proteins reflects the duration of the disease.
Keywords:
COVID-19; SARS-CoV-2; antibodies; dynamics; humoral immunity.
MeSH terms
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Antibodies, Viral / blood*
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Antigens, Viral / genetics
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Antigens, Viral / immunology*
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COVID-19 / blood
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COVID-19 / diagnosis*
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COVID-19 / immunology
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COVID-19 / virology
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Coronavirus Nucleocapsid Proteins / genetics
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Coronavirus Nucleocapsid Proteins / immunology*
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Enzyme-Linked Immunosorbent Assay
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Humans
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Immunity, Humoral
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Immunoglobulin G / blood*
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Immunoglobulin M / blood*
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SARS-CoV-2 / immunology
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SARS-CoV-2 / pathogenicity
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Spike Glycoprotein, Coronavirus / genetics
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Spike Glycoprotein, Coronavirus / immunology*
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Time Factors
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Virion / genetics
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Virion / immunology
Substances
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Antibodies, Viral
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Antigens, Viral
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Coronavirus Nucleocapsid Proteins
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Immunoglobulin G
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Immunoglobulin M
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Spike Glycoprotein, Coronavirus
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spike protein, SARS-CoV-2