RESUMEN: A flexible class of multi-parameter qMRI protocols

Abstract

Purpose: To introduce a class of fast 3D quantitative MRI (qMRI) schemes (RESUME^N, for N=1,…,4) that allow for a thorough characterization of microstructural properties of brain tissues.

Methods: An arbitrary multi-echo GRE acquisition optimized for quantitative susceptibility mapping (QSM) is complemented with an appropriate low flip-angle GRE sequence drawn from four possible choices. The acquired signals are processed to analytically derive the longitudinal relaxation (R₁) and free induction decay (R₂^∗) rates, as well as the proton density (PD) and QSM. A comprehensive modeling of the excitation and B₁^- profiles and of the RF-spoiling is included in the acquisition and processing pipeline.

Results: The RESUME^N maps appear homogeneous throughout the field-of-view and exhibit comparable values and high SNR across the considered range of N values.

Conclusions: The introduced schemes represent a class of robust and flexible strategies to derive a thorough and fast qMRI study, suitable for a whole-brain acquisition with isotropic voxel resolution of 700 μm in less than 15 min.

Keywords: Neuroimaging; QSM; Quantitative MRI; Relaxometry.