Starch-based magnetic nanocomposite as an efficient absorbent for anticancer drug removal from aqueous solution

Kun Fang; Kai Li; Tonghan Yang; Jianbin Li; Wei He

doi:10.1016/j.ijbiomac.2021.06.103

Starch-based magnetic nanocomposite as an efficient absorbent for anticancer drug removal from aqueous solution

Int J Biol Macromol. 2021 Aug 1:184:509-521. doi: 10.1016/j.ijbiomac.2021.06.103. Epub 2021 Jun 24.

Authors

Kun Fang¹, Kai Li², Tonghan Yang³, Jianbin Li⁴, Wei He⁵

Affiliations

¹ School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China; College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, Guangxi, China; School of Resources, Environment and Materials, Guangxi Key Laboratory of Processing for Non-ferrous Metallic and Featured Materials, Guangxi University, Nanning 530004, Guangxi, China.
² College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, Guangxi, China; The Collaborative Innovation Center for Guangxi Sugar Industry, Nanning 530004, Guangxi, China.
³ School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China; School of Resources, Environment and Materials, Guangxi Key Laboratory of Processing for Non-ferrous Metallic and Featured Materials, Guangxi University, Nanning 530004, Guangxi, China.
⁴ College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, Guangxi, China; The Collaborative Innovation Center for Guangxi Sugar Industry, Nanning 530004, Guangxi, China. Electronic address: lijb0771@sina.com.
⁵ School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China; School of Resources, Environment and Materials, Guangxi Key Laboratory of Processing for Non-ferrous Metallic and Featured Materials, Guangxi University, Nanning 530004, Guangxi, China. Electronic address: wei_he@gxu.edu.cn.

PMID: 34171254
DOI: 10.1016/j.ijbiomac.2021.06.103

Abstract

In this study, carboxymethyl cassava starch (CMCS)-functionalized magnetic nanoparticles (CMCS@Fe₃O₄) were synthesized via a simple one-pot co-precipitation method using CMCS materials with varying degrees of substitution, and used for the adsorption/removal of doxorubicin hydrochloride (Dox; a clinically available anti-cancer drug) from aqueous solution. The adsorption of Dox was studied using experimental conditions with varied pH, temperature, initial Dox concentration, and CMCS@Fe₃O₄ dosage. The CMCS@Fe₃O₄ adsorbents were characterized by scanning electron microscopy, transmission electron microscopy, infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and vibrating sample magnetometry. Each CMCS@Fe₃O₄ adsorbent exhibited a cubic inverse spinel iron oxide phase, small particle size, favorable magnetic properties, and good thermal stability. Batch adsorption experiments showed that the Dox adsorption efficiency reached 85.46% at a CMCS@Fe₃O₄ concentration of 20 mg mL^-1 at 303 K in pH 7.0. The adsorption experimental results indicated that the adsorption kinetics followed a pseudo-second-order model and the Langmuir equation. Considering the environmentally nontoxic nature of Fe₃O₄ and starch, the CMCS@Fe₃O₄ material demonstrated significant potential for removing Dox from aqueous solution and in magnetic targeted drug delivery systems for synergistic tumor treatments.

Keywords: Adsorption; Carboxymethylation; Cassava starch; Doxorubicin; Iron oxide nanoparticles.

MeSH terms

Antineoplastic Agents / analysis*
Doxorubicin / analysis*
Hydrogen-Ion Concentration
Magnetic Phenomena
Magnetite Nanoparticles
Manihot / chemistry*
Nanocomposites
Particle Size
Starch / analogs & derivatives*
Starch / chemistry
Temperature
Water Pollutants, Chemical / analysis*
X-Ray Diffraction

Substances

Antineoplastic Agents
Magnetite Nanoparticles
Water Pollutants, Chemical
Doxorubicin
Starch
carboxymethyl starch