Ether phospholipids govern ferroptosis

Hyemin Lee; Li Zhuang; Boyi Gan

doi:10.1016/j.jgg.2021.05.003

Ether phospholipids govern ferroptosis

J Genet Genomics. 2021 Jul 20;48(7):517-519. doi: 10.1016/j.jgg.2021.05.003. Epub 2021 Jun 1.

Authors

Hyemin Lee¹, Li Zhuang¹, Boyi Gan²

Affiliations

¹ Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
² Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. Electronic address: bgan@mdanderson.org.

Abstract

Ferroptosis is a cell death modality triggered by excessive lipid peroxidation. Two recent studies (Zou et al., 2020; Cui et al., 2021) not only reveal critical roles of ether-linked phospholipids as an additional source for providing polyunsaturated fatty acid-containing phospholipids in driving ferroptosis but also suggest a context-dependent role of TMEM189-mediated vinyl-ether phospholipid (plasmalogen) synthesis in ferroptosis.

Keywords: Ether phospholipids; Ferroptosis; Lipid peroxidation; Plasmalogen; TMEM189.

Ether phospholipids govern ferroptosis

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Abstract

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