NIR-II Responsive Hollow Magnetite Nanoclusters for Targeted Magnetic Resonance Imaging-Guided Photothermal/Chemo-Therapy and Chemodynamic Therapy

Xingyu Wang; Changwei Li; Junchao Qian; Xiaotong Lv; Hong Li; Jinglu Zou; Jiahui Zhang; Xiangfu Meng; Hongji Liu; Yong Qian; Wenchu Lin; Hui Wang

doi:10.1002/smll.202100794

NIR-II Responsive Hollow Magnetite Nanoclusters for Targeted Magnetic Resonance Imaging-Guided Photothermal/Chemo-Therapy and Chemodynamic Therapy

Small. 2021 Aug;17(31):e2100794. doi: 10.1002/smll.202100794. Epub 2021 Jun 24.

Authors

Xingyu Wang^{1

2}, Changwei Li³, Junchao Qian^{4

5}, Xiaotong Lv^{1

2}, Hong Li¹, Jinglu Zou¹, Jiahui Zhang^{1

2}, Xiangfu Meng^{1

2}, Hongji Liu¹, Yong Qian¹, Wenchu Lin^{1

6}, Hui Wang^{1

6

7}

Affiliations

¹ High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, AH 230031, P. R. China.
² University of Science and Technology of China, Hefei, AH 230026, P. R. China.
³ Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Traumatology and Orthopedics, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Huangpu, SH 200025, P. R. China.
⁴ Hefei Cancer Hospital, Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, AH 230031, P. R. China.
⁵ Department of Radiation Oncology, School of Medicine, Shandong University, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, SD, 250117, P. R. China.
⁶ Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, AH 230026, P. R. China.
⁷ The Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, AH 230026, P. R. China.

PMID: 34165871
DOI: 10.1002/smll.202100794

Abstract

Phototherapy in the second near-IR (1000-1700 nm, NIR-II) window has achieved much progress because of its high efficiency and relatively minor side effects. In this paper, a new NIR-II responsive hollow magnetite nanocluster (HMNC) for targeted and imaging-guided cancer therapy is reported. The HMNC not only provides a hollow cavity for drug loading but also serves as a contrast agent for tumor-targeted magnetic resonance imaging. The acid-induced dissolution of the HMNCs can trigger a pH-responsive drug release for chemotherapy and catalyze the hydroxyl radical (·OH) formation from the decomposition of hydrogen peroxide for chemodynamic therapy. Moreover, the HMNCs can adsorb and convert NIR-II light into local heat (photothermal conversion efficacy: 36.3%), which can accelerate drug release and enhance the synergistic effect of chemo-photothermal therapy. The HMNCs show great potential as a versatile nanoplatform for targeted imaging-guided trimodal cancer therapy.

Keywords: NIR-II absorption; chemodynamic therapy; hollow magnetite nanoclusters; photothermal therapy; responsive drug release.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Doxorubicin
Drug Liberation
Ferrosoferric Oxide
Hyperthermia, Induced*
Magnetic Resonance Imaging
Nanoparticles*
Phototherapy

Substances

Doxorubicin
Ferrosoferric Oxide