An Immune-Related Signature Predicted Survival in Patients With Kidney Papillary Cell Carcinoma

Junwen Shen; Rongjiang Wang; Yu Chen; Zhihai Fang; Jianer Tang; Jianxiang Yao; Yuhang Ling; Lisha Zhang; Xu Zhang

doi:10.3389/fonc.2021.670047

An Immune-Related Signature Predicted Survival in Patients With Kidney Papillary Cell Carcinoma

Front Oncol. 2021 Jun 7:11:670047. doi: 10.3389/fonc.2021.670047. eCollection 2021.

Authors

Junwen Shen¹, Rongjiang Wang¹, Yu Chen¹, Zhihai Fang¹, Jianer Tang¹, Jianxiang Yao¹, Yuhang Ling¹, Lisha Zhang¹, Xu Zhang²

Affiliations

¹ The First Hospital of Huzhou, Huzhou, China.
² Zhejiang University of Science and Technology, Hangzhou, China.

Abstract

Immune-related genes are important factors in tumor progression. The main aim of this study was to identify the immune-related genes in kidney papillary cell carcinoma (pRCC) patients. We downloaded RNAseq data and clinical information of pRCC patients from the TCGA database and retrieved the immune-related genes list from Immport. From the data, we mined out 2,468 differential expression genes (DEGs) and 183 immune-related DEGs. Four hub DEGs (NTS, BIRC5, ELN, and CHGA) were identified after conducting Cox analysis and LASSO analysis. Moreover, the prognostic value of the signature based on four hub DEGs was verified using Kaplan-Meier analysis (P = 0.0041 in the training set and p = 0.021 in the test set) and ROC analysis (AUC: 0.957 in 1 year, 0.965 in 2 years, and 0.901 in 3 years in the training set, and 0.963 in 1 year, 0.898 in 2 years, and 0.742 in 3 years in the test set). Furthermore, we found that the high-risk score group had a higher percentage of B cells in the immune component, a higher expression of immune-related genes (CTLA4, LAG3, PDCD1LG2, and TIGIT), and a better immunotherapy response.

Keywords: genes; immune-related; kidney papillary cell carcinoma; prognostic; signature.