Urine APOL1 Isoforms Reflect Plasma-Derived Liver-Synthesized Proteins

Magnus Althage; Timothy M Heinrich; Tasso Miliotis; Anna Bogstedt; Lijun Ma; Michael D Gautreaux; Pamela J Hicks; Nicholette D Palmer; Iain MacPhee; Judith Hartleib-Geschwindner; Peter J Greasley; Barry I Freedman

doi:10.1681/ASN.2021030411

Urine APOL1 Isoforms Reflect Plasma-Derived Liver-Synthesized Proteins

J Am Soc Nephrol. 2021 Oct;32(10):2442-2444. doi: 10.1681/ASN.2021030411. Epub 2021 Jun 23.

Affiliations

¹ Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
² Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
³ Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
⁴ Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina.

No abstract available

Keywords: APOL1; end-stage renal disease; ethnic minority; focal segmental glomerulosclerosis; genetic renal disease; human genetics; hypertension; kidney; kidney disease; kidney transplantation.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Apolipoprotein L1 / blood
Apolipoprotein L1 / genetics*
Apolipoprotein L1 / urine*
Female
Genetic Variation
Genotype*
Humans
Kidney / metabolism*
Kidney Transplantation
Male
Middle Aged
Postoperative Period
Protein Isoforms / blood
Protein Isoforms / genetics
Protein Isoforms / urine

Substances

APOL1 protein, human
Apolipoprotein L1
Protein Isoforms