Fluid metabolic pathways after subarachnoid hemorrhage

J Neurochem. 2022 Jan;160(1):13-33. doi: 10.1111/jnc.15458. Epub 2021 Jul 12.

Abstract

Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating cerebrovascular disease with high mortality and morbidity. In recent years, a large number of studies have focused on the mechanism of early brain injury (EBI) and delayed cerebral ischemia (DCI), including vasospasm, neurotoxicity of hematoma and neuroinflammatory storm, after aSAH. Despite considerable efforts, no novel drugs have significantly improved the prognosis of patients in phase III clinical trials, indicating the need to further re-examine the multifactorial pathophysiological process that occurs after aSAH. The complex pathogenesis is reflected by the destruction of the dynamic balance of the energy metabolism in the nervous system after aSAH, which prevents the maintenance of normal neural function. This review focuses on the fluid metabolic pathways of the central nervous system (CNS), starting with ruptured aneurysms, and discusses the dysfunction of blood circulation, cerebrospinal fluid (CSF) circulation and the glymphatic system during disease progression. It also proposes a hypothesis on the metabolic disorder mechanism and potential therapeutic targets for aSAH patients. Cover Image for this issue: https://doi.org/10.1111/jnc.15384.

Keywords: cerebrospinal fluid circulation; cerebrum microdialysis; energy metabolism; glymphatic system; microcirculation disturbance; subarachnoid hemorrhage.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / metabolism
  • Brain / physiopathology
  • Cerebrovascular Circulation / physiology*
  • Glymphatic System / physiology*
  • Humans
  • Metabolic Networks and Pathways / physiology*
  • Subarachnoid Hemorrhage / metabolism*
  • Subarachnoid Hemorrhage / physiopathology*