Experimental modeling of selective photodestruction of skin angiodysplasia by laser radiation with a wavelength of 525 nm

Abstract

Until now, the problem of effective treatment of skin angiodysplasia remains relevant. To solve it and improve the results of the treatment of this vascular pathology of the skin, photodestruction by laser radiation is considered, which provides a selective effect on the skin with minimal damage to the surrounding tissues. For selective photodestruction in the treatment of angiodysplasia of the skin, one can consider laser radiation with a wavelength of 520 ± 5 nm in the "green" spectral range, located close to the absorption peaks of hemoglobin and oxyhemoglobin chromophores. An experimental study in vivo on the combs of live white chickens was carried out to clarify the features of damage and the regeneration process in the zone of exposure to this radiation. We used an experimental sample of a solid-state laser apparatus based on semiconductor diodes, generating laser radiation with a wavelength of 520 ± 5 nm. The results of an experimental study in vivo confirmed the selectivity of the effect of "green" laser radiation of 520 ± 5 nm on subepithelial vascular structures with minimal damage to the epithelium, including the area of its growth. In irradiated areas, one could see whitening and smoothing of the surface due to closure of vessel lumens in the subepithelial zone and formation of collagenosis layer there, as well as epithelialization of wound surface in physiological term without any formation of cicatricial deformation of the skin. The prospect of using "green" laser radiation of 520 ± 5 nm for the purposes of selective photodestruction of angiodysplasia of the skin, which should ensure the achievement of a good clinical and aesthetic result of treatment, has been effective for selective destruction of angiodysplasia.

Keywords: Angiodysplasia of the skin; Laser radiation of the green spectral range; Morphological study; Selective photodestruction.