Change in hair growth-related gene expression profile in human isolated hair follicles induced by 5-alpha reductase inhibitors - dutasteride and finasteride - in the presence of testosterone

Singapore Med J. 2022 Sep;63(9):552-558. doi: 10.11622/smedj.2021080. Epub 2021 Jan 22.

Authors

Toshiki Hatanaka¹, Zrinka Lulic², Tim Mefo³, Cath Booth³, Elliott Harrison³, Gary Ong⁴

Affiliations

¹ Department of Medical Affairs, Medical Division, GlaxoSmithKline KK, Akasaka, Minato-ku, Tokyo, Japan.
² Pharma Research and Development, Global Medical, GlaxoSmithKline, Brentford, Middlesex, UK.
³ Personalised Medicine - Pharmacogenomics Division, Epistem Ltd, Manchester, UK.
⁴ Pharma Research and Development, Global Medical, GlaxoSmithKline Pte Ltd, Singapore.

No abstract available

MeSH terms

5-alpha Reductase Inhibitors* / pharmacology
Dutasteride / pharmacology
Finasteride* / pharmacology
Hair / metabolism
Hair Follicle / metabolism
Humans
Testosterone / metabolism
Testosterone / pharmacology
Transcriptome

Substances

Finasteride
Dutasteride
5-alpha Reductase Inhibitors
Testosterone