Engineering bionanoparticles for improved biosensing and bioimaging

Daniel Yur; Rachel M Lieser; Millicent O Sullivan; Wilfred Chen

doi:10.1016/j.copbio.2021.06.002

Engineering bionanoparticles for improved biosensing and bioimaging

Curr Opin Biotechnol. 2021 Oct:71:41-48. doi: 10.1016/j.copbio.2021.06.002. Epub 2021 Jun 19.

Authors

Daniel Yur¹, Rachel M Lieser¹, Millicent O Sullivan², Wilfred Chen³

Affiliations

¹ Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy Street, Newark, DE 19716 United States.
² Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy Street, Newark, DE 19716 United States. Electronic address: msullivan@udel.edu.
³ Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy Street, Newark, DE 19716 United States. Electronic address: wilfred@udel.edu.

PMID: 34157601
DOI: 10.1016/j.copbio.2021.06.002

Abstract

The importance of bioimaging and biosensing has been clear with the onset of the COVID-19 pandemic. In addition to viral detection, detection of tumors, glucose levels, and microbes is necessary for improved disease treatment and prevention. Bionanoparticles, such as extracellular vesicles and protein nanoparticles, are ideal platforms for biosensing and bioimaging applications because of their propensity for high density surface functionalization and large loading capacity. Scaffolding large numbers of sensing modules and detection modules onto bionanoparticles allows for enhanced analyte affinity and specificity as well as signal amplification for highly sensitive detection even at low analyte concentrations. Here we demonstrate the potential of bionanoparticles for bioimaging and biosensing by highlighting recent examples in literature that utilize protein nanoparticles and extracellular vesicles to generate highly sensitive detection devices with impressive signal amplification.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Biosensing Techniques*
COVID-19*
Humans
Nanoparticles*
Pandemics
SARS-CoV-2