Understanding totipotency: A role for alternative splicing

Alejandro De Los Angeles; Pentao Liu

doi:10.1016/j.devcel.2021.06.002

Understanding totipotency: A role for alternative splicing

Dev Cell. 2021 Jun 21;56(12):1697-1699. doi: 10.1016/j.devcel.2021.06.002.

Authors

Alejandro De Los Angeles¹, Pentao Liu²

Affiliations

¹ Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
² School of Biomedical Science, Stem Cell and Regenerative Consortium, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong; Center for Translational Stem Cell Biology, Hong Kong Science and Technology Park, Hong Kong. Electronic address: pliu88@hku.hk.

PMID: 34157304
DOI: 10.1016/j.devcel.2021.06.002

Abstract

Totipotency refers to single cells' developmental capacity to form an entire organism. Understanding how totipotent stem cells form has implications for chimera generation. In a recent Cell study, Shen et al. (2021) report that inhibition of spliceosomes resets conventional pluripotent stem cells to a cellular state with totipotency features.

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MeSH terms

Alternative Splicing / genetics
Cell Differentiation
Embryonic Stem Cells*
Pluripotent Stem Cells*
Totipotent Stem Cells