The First Case of Immunity Loss and SARS-CoV-2 Reinfection by the Same Virus Lineage in Amazonia

Lucas Ferrante; Sophia Livas; Wilhelm Alexander Steinmetz; Alexandre Celestino Leite Almeida; Jeremias Leão; Ruth Camargo Vassão; Unaí Tupinambás; Philip Martin Fearnside; Luiz Henrique Duczmal

doi:10.1007/s40615-021-01084-7

The First Case of Immunity Loss and SARS-CoV-2 Reinfection by the Same Virus Lineage in Amazonia

J Racial Ethn Health Disparities. 2021 Aug;8(4):821-823. doi: 10.1007/s40615-021-01084-7. Epub 2021 Jun 21.

Authors

Lucas Ferrante¹, Sophia Livas², Wilhelm Alexander Steinmetz³, Alexandre Celestino Leite Almeida⁴, Jeremias Leão⁵, Ruth Camargo Vassão⁶, Unaí Tupinambás⁷, Philip Martin Fearnside⁸, Luiz Henrique Duczmal⁹

Affiliations

¹ Programa de Pós-Graduação em Biologia (Ecologia), Instituto Nacional de Pesquisas da Amazônia (INPA), Manaus, Amazonas, Brazil. lucasferrante@hotmail.com.
² Programa de Pós-Graduação em Saúde, Sociedade e Endemias na Amazônia (PPG-SEA-M), Universidade Federal do Amazonas (UFAM), Manaus, Amazonas, Brazil.
³ Department of Mathematics, Universidade Federal do Amazonas (UFAM), Manaus, Amazonas, Brazil.
⁴ Universidade Federal de São João del-Rei (UFSJ)-DEFIM, Ouro Branco, Minas Gerais, Brazil.
⁵ Department of Statistics, Universidade Federal do Amazonas (UFAM), Manaus, Amazonas, Brazil.
⁶ Cell Biology Laboratory of the Instituto Butantan-São Paulo, São Paulo, Brazil.
⁷ Department of Internal Medicine, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
⁸ Departamento de Dinâmica Ambiental, Instituto Nacional de Pesquisas da Amazônia (INPA), Manaus, Amazonas, Brazil.
⁹ Department of Statistics, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.

Abstract

We report the first confirmed record of a SARS-CoV-2 immunity loss and reinfection for the Amazon region and for Brazil by the same virus lineage. The patient presented an asymptomatic condition the first time and an aggravated one after reinfection. We raise the possibility of a recessive genotype in the Amazonian population that does not generate an immune memory response to SARS-CoV-2.

Keywords: Amazonas; COVID-19; Immunity loss; Manaus.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Brazil
COVID-19 / immunology*
Female
Humans
Reinfection / virology*
SARS-CoV-2 / genetics
SARS-CoV-2 / immunology*
Young Adult