Upon clinical and pathological analyses of the evidence obtained on drug-related lethal nephropathies (51 cases) and hepatopathies (14 cases) as well as at puncture biopsies of the livers affected by chemotherapeutic agents it was determined that the commonest variants of the disturbances were tubular nephropathies, tubular-interstitial nephritis, papillary renal necrosis, symmetric cortical renal necrosis, fulminant hepatopathies with diffuse massive necrosis of hepatocytes. For biopsies, cholestatic drug-induced hepatopathies were found most frequently. As a rule, the patients received polychemotherapy with psychotropic, cardiovascular and antidiabetic drugs, nonsteroids, antibiotics, sulfanilamides, consumed contrast diagnostic media. The attention is drawn to considerable diagnostic difficulties faced in drug-induced damage to the organs which can be diminished by comparisons between clinical and morphological findings.