Science is facing a new RNA world that is shaping our knowledge, and we are discovering a new horizon in molecular biology. New technologies revealed thousands and thousands of new RNAs, most of them located in what was once known as the "dark matter of DNA". They are functional regulatory RNAs and do not code for proteins, and they orchestrate the cellular function according to the changes needed. These noncoding RNAs are ubiquitous, and they are present from viruses to humans. In this Virtual Issue, The FEBS Journal features a collection of recent articles on long noncoding RNAs, microRNAs, and circular RNAs. It gives a broad perspective regarding their role in vascular diseases, ocular diseases, immune cell development and homeostasis, inflammation, production of extracellular matrix, and cancer. Furthermore, review-type articles highlight the potential use of noncoding RNAs in a wide range of applications.
Keywords: circRNA; disease; functional RNA; gene expression; lncRNA; microRNA; noncoding RNA; regulatory RNA.
© 2021 Federation of European Biochemical Societies.