We found severe acute respiratory syndrome coronavirus 2 RNA in 6 (8.4%) of 71 ferrets in central Spain and isolated and sequenced virus from 1 oral and 1 rectal swab specimen. Natural infection occurs in kept ferrets when virus circulation among humans is high. However, small ferret collections probably cannot maintain virus circulation.
Keywords: COVID-19; SARS-CoV-2; Spain; coronavirus disease; ferrets; mustela putorius furo; natural infection; pets; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; work animals; zoonoses.