Hydrosilane-Mediated Electrochemical Reduction of Amides

J Org Chem. 2021 Nov 19;86(22):15992-16000. doi: 10.1021/acs.joc.1c00931. Epub 2021 Jun 21.

Abstract

Electrochemical reduction of amides was achieved by using a hydrosilane without any toxic or expensive metals. The key reactive ketyl radical intermediate was generated by cathodic reduction. Continuous reaction with anodically generated silyl radicals or zinc bromide resulted in chemoselective deoxygenation to give the corresponding amines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides*
  • Amines*

Substances

  • Amides
  • Amines