Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk

Alina Solomon; Ron Handels; Anders Wimo; Riitta Antikainen; Tiina Laatikainen; Esko Levälahti; Markku Peltonen; Hilkka Soininen; Timo Strandberg; Jaakko Tuomilehto; Miia Kivipelto; Tiia Ngandu

doi:10.3233/JAD-210331

Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk

J Alzheimers Dis. 2021;82(4):1461-1466. doi: 10.3233/JAD-210331.

Authors

Alina Solomon^{1

2}, Ron Handels^{3

4

5}, Anders Wimo⁵, Riitta Antikainen^{6

7

8}, Tiina Laatikainen^{9

10

11}, Esko Levälahti⁹, Markku Peltonen⁹, Hilkka Soininen^{1

12}, Timo Strandberg^{6

13}, Jaakko Tuomilehto^{9

14

15}, Miia Kivipelto^{1

2

10

16}, Tiia Ngandu^{2

9}

Affiliations

¹ Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.
² Karolinska Institutet, NVS, Division of Clinical Geriatrics, Solna, Stockholm, Sweden.
³ Alzheimer Centre Limburg, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
⁴ Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.
⁵ Karolinska Institutet, NVS, Division of Neurogeriatrics, Stockholm, Sweden.
⁶ Center for Life Course Health Research, University of Oulu, Oulu, Finland.
⁷ Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland.
⁸ Oulu City Hospital, Oulu, Finland.
⁹ Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
¹⁰ Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
¹¹ Hospital District of North Karelia, Joensuu, Finland.
¹² Neurocenter, Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
¹³ University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
¹⁴ Department of Public Health, University of Helsinki, Helsinki, Finland.
¹⁵ National School of Public Health, Madrid, Spain.
¹⁶ Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, United Kingdom.

Abstract

We investigated the effect of a multidomain lifestyle intervention on the risk of dementia estimated using the validated CAIDE risk score (post-hoc analysis). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a 2-year randomized controlled trial among 1,260 at-risk older adults (60-77 years). Difference in the estimated mean change in CAIDE score at 2 years in the intervention compared to the control group was -0.16 (95 %CI -0.31 to 0.00) (p = 0.013), corresponding to a relative dementia risk reduction between 6.04-6.50%. This could be interpreted as a reflection of the prevention potential of the intervention.

Keywords: Clinical trial; dementia; dementia risk score; lifestyle intervention; prevention.

Publication types

Letter
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Cognitive Dysfunction / prevention & control*
Dementia / prevention & control*
Exercise / physiology*
Female
Finland
Humans
Life Style*
Male
Nutrition Assessment*
Risk Factors
Risk Reduction Behavior*