Potential Gene Association Studies of Chemotherapy-Induced Cardiotoxicity: A Systematic Review and Meta-Analysis

Xinyu Yang; Guoping Li; Manke Guan; Aneesh Bapat; Qianqian Dai; Changming Zhong; Tao Yang; Changyong Luo; Na An; Wenjing Liu; Fan Yang; Haie Pan; Pengqian Wang; Yonghong Gao; Ye Gong; Saumya Das; Hongcai Shang; Yanwei Xing

doi:10.3389/fcvm.2021.651269

Potential Gene Association Studies of Chemotherapy-Induced Cardiotoxicity: A Systematic Review and Meta-Analysis

Front Cardiovasc Med. 2021 Jun 4:8:651269. doi: 10.3389/fcvm.2021.651269. eCollection 2021.

Authors

Xinyu Yang^{1

2

3}, Guoping Li³, Manke Guan¹, Aneesh Bapat³, Qianqian Dai¹, Changming Zhong¹, Tao Yang¹, Changyong Luo⁴, Na An^{1

2}, Wenjing Liu¹, Fan Yang², Haie Pan¹, Pengqian Wang^{1

5}, Yonghong Gao¹, Ye Gong⁶, Saumya Das³, Hongcai Shang¹, Yanwei Xing²

Affiliations

¹ Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.
² Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
³ Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
⁴ College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
⁵ Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
⁶ Department of Critical Care Medicine, Shanghai Medical College, Huashan Hospital, Fudan University, Shanghai, China.

Abstract

Chemotherapy is widely used in the treatment of cancer patients, but the cardiotoxicity induced by chemotherapy is still a major concern to most clinicians. Currently, genetic methods have been used to detect patients with high risk of chemotherapy-induced cardiotoxicity (CIC), and our study evaluated the correlation between genomic variants and CIC. The systematic literature search was performed in the PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), China Biology Medicine disc (CBMdisc), the Embase database, China National Knowledge Internet (CNKI) and Wanfang database from inception until June 2020. Forty-one studies were identified that examined the relationship between genetic variations and CIC. And these studies examined 88 different genes and 154 single nucleotide polymorphisms (SNPs). Our study indicated 6 variants obviously associated with the increased risk for CIC, including CYBA rs4673 (pooled odds ratio, 1.93; 95% CI, 1.13-3.30), RAC2 rs13058338 (2.05; 1.11-3.78), CYP3A5 rs776746 (2.15; 1.00-4.62) ABCC1 rs45511401 (1.46; 1.05-2.01), ABCC2 rs8187710 (2.19; 1.38-3.48), and HER2-Ile655Val rs1136201 (2.48; 1.53-4.02). Although further studies are required to validate the diagnostic and prognostic roles of these 6 variants in predicting CIC, our study emphasizes the promising benefits of pharmacogenomic screening before chemotherapy to minimize the CIC.

Keywords: SNPs; cardiotoxicity; chemotherapy; gene; meta-analysis.

Publication types

Systematic Review