A rare case of B cell lymphoblastic leukemia with inv(7)(p15q34) with review of literature

Bernhisel Andrew; Orazi Attilio; Guar Sumit; Tonk Vijay; Ghafouri Sayed Reshad; Padilla Osvaldo

doi:10.1016/j.lrr.2021.100250

A rare case of B cell lymphoblastic leukemia with inv(7)(p15q34) with review of literature

Leuk Res Rep. 2021 Jun 1:15:100250. doi: 10.1016/j.lrr.2021.100250. eCollection 2021.

Authors

Bernhisel Andrew¹, Orazi Attilio², Guar Sumit³, Tonk Vijay⁴, Ghafouri Sayed Reshad³, Padilla Osvaldo²

Affiliations

¹ Medical student, Paul Foster School of Medicine, Texas Tech Health Sciences Center at El Paso, TX.
² Department of Pathology, Texas Tech Health Sciences Center at El Paso, TX.
³ Department of Internal Medicine, Texas Tech Health Sciences Center at El Paso, TX.
⁴ Department of Pediatrics, Texas Tech Health Sciences Center at Lubbock, TX.

Abstract

The inv(7)(p15q34) chromosomal abnormality which juxtaposes part of the HOXA gene cluster on 7p15 to the TCRβ locus on 7q34, has been described in a subset of cases of T-cell lymphoblastic leukemia, but its presence in cases of B-cell lymphoblastic leukemia is virtually unknown. Herewith, we report a case of a B-cell lymphoblastic leukemia with inv(7)(p15q34). The patient received standard induction chemotherapy, which failed to produce remission. After treatment with blinatumomab, a bispecific T-cell engager, the follow-up bone marrow biopsy showed no evidence of persistent/ relapsed B-cell lymphoblastic leukemia. The unique cytogenetics of this case may have contributed to its resistance of standard induction chemotherapy.

Publication types

Case Reports