A Comparison of CVR Magnitude and Delay Assessed at 1.5 and 3T in Patients With Cerebral Small Vessel Disease

Michael S Stringer; Gordon W Blair; Yulu Shi; Iona Hamilton; David A Dickie; Fergus N Doubal; Ian M Marshall; Michael J Thrippleton; Joanna M Wardlaw

doi:10.3389/fphys.2021.644837

A Comparison of CVR Magnitude and Delay Assessed at 1.5 and 3T in Patients With Cerebral Small Vessel Disease

Front Physiol. 2021 Jun 2:12:644837. doi: 10.3389/fphys.2021.644837. eCollection 2021.

Authors

Michael S Stringer^{1

2}, Gordon W Blair^{1

2}, Yulu Shi^{1

3}, Iona Hamilton^{1

2}, David A Dickie⁴, Fergus N Doubal^{1

2}, Ian M Marshall^{1

2}, Michael J Thrippleton^{1

2}, Joanna M Wardlaw^{1

2}

Affiliations

¹ Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
² UK Dementia Research Institute at the University of Edinburgh, Edinburgh, United Kingdom.
³ Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing, China.
⁴ College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

Abstract

Background: Cerebrovascular reactivity (CVR) measures blood flow change in response to a vasoactive stimulus. Impairment is associated with several neurological conditions and can be measured using blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI). Field strength affects the BOLD signal, but the effect on CVR is unquantified in patient populations.

Methods: We recruited patients with minor ischemic stroke and assessed CVR magnitude and delay time at 3 and 1.5 Tesla using BOLD MRI during a hypercapnic challenge. We assessed subcortical gray (GM) and white matter (WM) differences using Wilcoxon signed rank tests and scatterplots. Additionally, we explored associations with demographic factors, WM hyperintensity burden, and small vessel disease score.

Results: Eighteen of twenty patients provided usable data. At 3T vs. 1.5T: mean CVR magnitude showed less variance (WM 3T: 0.062 ± 0.018%/mmHg, range 0.035, 0.093; 1.5T: 0.057 ± 0.024%/mmHg, range 0.016, 0.094) but was not systematically higher (Wilcoxon signal rank tests, WM: r = -0.33, confidence interval (CI): -0.013, 0.003, p = 0.167); delay showed similar variance (WM 3T: 40 ± 12 s, range: 12, 56; 1.5T: 31 ± 13 s, range 6, 50) and was shorter in GM (r = 0.33, CI: -2, 9, p = 0.164) and longer in WM (r = -0.59, CI: -16, -2, p = 0.010). Patients with higher disease severity tended to have lower CVR at 1.5 and 3T.

Conclusion: Mean CVR magnitude at 3T was similar to 1.5T but showed less variance. GM/WM delay differences may be affected by low signal-to-noise ratio among other factors. Although 3T may reduce variance in CVR magnitude, CVR is readily assessable at 1.5T and reveals comparable associations and trends with disease severity.

Keywords: BOLD signal; cerebrovascular reactivity; magnetic resonance imaging; small vessel disease; stroke.

Abstract

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