Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases

Qingyun Tan; Yuying Fang; Qiong Gu

doi:10.3389/fphar.2021.657033

Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases

Front Pharmacol. 2021 Jun 4:12:657033. doi: 10.3389/fphar.2021.657033. eCollection 2021.

Authors

Qingyun Tan¹, Yuying Fang¹, Qiong Gu¹

Affiliation

¹ Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.

Abstract

Ferroptosis is a new form of programmed cell death characterized by intracellular iron-dependent accumulation of lipid peroxide and primarily associated with iron metabolism, glutathione-dependent pathway, and coenzyme Q₁₀-dependent pathway. Recent studies demonstrate that ferroptosis is associated with central nervous system (CNS) diseases, such as stroke, Parkinson's disease, Alzheimer's disease, and Huntington's disease. This review summarizes the key regulatory mechanisms of ferroptosis and its role in CNS diseases. These updates may provide novel perspective for the development of therapeutical agents against CNS diseases.

Keywords: central nervous system diseases; coenzyme Q10; ferroptosis; glutathione peroxidase 4; iron metabolism; lipid metabolism.

Publication types

Review