No abstract available
Keywords:
BRAF fusion; MAPK pathway; lung adenocarcinoma; precision medicine; trametinib.
MeSH terms
-
Adenocarcinoma of Lung / drug therapy*
-
Adenocarcinoma of Lung / pathology
-
Aged
-
Humans
-
Intracellular Signaling Peptides and Proteins / drug effects*
-
LIM Domain Proteins / drug effects*
-
Lung Neoplasms / drug therapy*
-
Lung Neoplasms / pathology
-
Male
-
Mitogen-Activated Protein Kinase Kinases / pharmacology*
-
Mitogen-Activated Protein Kinase Kinases / therapeutic use*
-
Mutation
-
Protein Kinase Inhibitors / pharmacology*
-
Protein Kinase Inhibitors / therapeutic use*
-
Proto-Oncogene Proteins B-raf / drug effects*
-
Pyridones / pharmacology*
-
Pyridones / therapeutic use*
-
Pyrimidinones / pharmacology*
-
Pyrimidinones / therapeutic use*
Substances
-
Intracellular Signaling Peptides and Proteins
-
LIM Domain Proteins
-
LIMD1 protein, human
-
Protein Kinase Inhibitors
-
Pyridones
-
Pyrimidinones
-
trametinib
-
BRAF protein, human
-
Proto-Oncogene Proteins B-raf
-
Mitogen-Activated Protein Kinase Kinases