Analyses of the association between breast cancer and osteoporosis/fracture history: a cross-sectional study using KoGES HEXA data

Hyo Geun Choi; Yong Joon Suh; Jung Woo Lee; Chan Yang Min; Dae Myoung Yoo; Suk Woo Lee

doi:10.1007/s11657-021-00947-0

Analyses of the association between breast cancer and osteoporosis/fracture history: a cross-sectional study using KoGES HEXA data

Arch Osteoporos. 2021 Jun 19;16(1):98. doi: 10.1007/s11657-021-00947-0.

Authors

Hyo Geun Choi^{1

2}, Yong Joon Suh³, Jung Woo Lee⁴, Chan Yang Min¹, Dae Myoung Yoo¹, Suk Woo Lee^{5

6}

Affiliations

¹ Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Republic of Korea.
² Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Anyang, Republic of Korea.
³ Department of Breast and Endocrine Surgery, Hallym University College of Medicine, Anyang, Republic of Korea.
⁴ Department of Orthopedic Surgery, Yonsei University Wonju College of Medicine, Wonju, South Korea.
⁵ Department of Obstetrics and Gynecology, Hallym University College of Medicine, Anyang, Republic of Korea. ssugucap@naver.com.
⁶ Department of Obstetrics and Gynecology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, 22 Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang-si, Gyeonggi-do, 14068, Republic of Korea. ssugucap@naver.com.

PMID: 34148148
DOI: 10.1007/s11657-021-00947-0

Abstract

We performed a nationwide, population-based cohort study to evaluate the risk of osteoporosis and osteoporotic fracture in patients with breast cancer using the data from Korean Genome and Epidemiology Study (KoGES) and concluded that Korean women with breast cancer had a higher risk of osteoporosis than healthy women, regardless of age.

Purpose: This study aimed to evaluate the association between breast cancer and the occurrence of osteoporosis and osteoporotic fracture using data from the Korean Genome and Epidemiology Study (KoGES).

Methods: Using the national KoGES health examinee (HEXA) data consisting of data from urban resident participants ≥ 40 years old, we extracted data for patients with breast cancer (n = 1080) and for control participants (n = 106,993); we then analyzed the occurrence of osteoporosis and osteoporotic fracture at baseline from 2004 to 2013 and during follow-up from 2012 to 2016. A logistic regression model was used to analyze the odds ratios (ORs) and the 95% confidence intervals (CIs). Subgroup analysis was performed based on age (younger group aged ≤ 51 years old; older group aged ≥ 52 years old).

Results: The ORs (95% CIs) for osteoporosis and osteoporotic fracture were 1.54 (95% CI = 1.28-1.84, P < 0.001) and 1.01 (95% CI = 0.82-1.23, P = 0.949), respectively, in the breast cancer group. In the subgroup analysis based on age, the ORs (95% CIs) for osteoporosis were 2.41 (95% CI = 1.70-3.43, P < 0.001) in the younger group and 1.33 (95% CI = 1.08-1.64, P = 0.007) in the older group of breast cancer patients. The ORs (95% CIs) for osteoporotic fracture were 1.15 (95% CI = 0.81-1.63, P = 0.441) in the younger group and 0.95 (95% CI = 0.74-1.21, P = 0.661) in the older group of breast cancer patients.

Conclusion: We concluded that Korean women with breast cancer had a higher risk of osteoporosis than healthy women, but the same finding was not observed for osteoporotic fracture, regardless of age.

Keywords: Breast cancer; Cohort study; Korea Genome and Epidemiology Study; Nested case–control study; Osteoporosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Breast Neoplasms*
Cohort Studies
Cross-Sectional Studies
Female
Humans
Middle Aged
Osteoporosis*
Osteoporotic Fractures*
Risk Factors