Zooming in on targets of mosquito small RNAs

Rebecca Halbach; Pascal Miesen; Ronald P van Rij

doi:10.1016/j.pt.2021.06.002

Zooming in on targets of mosquito small RNAs

Trends Parasitol. 2021 Aug;37(8):687-689. doi: 10.1016/j.pt.2021.06.002. Epub 2021 Jun 16.

Authors

Rebecca Halbach¹, Pascal Miesen¹, Ronald P van Rij²

Affiliations

¹ Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
² Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: ronald.vanrij@radboudumc.nl.

PMID: 34147336
DOI: 10.1016/j.pt.2021.06.002

Abstract

Small RNAs are crucial for the regulation of basic cellular processes and protection against viruses and transposons in mosquitoes. Rozen-Gagnon et al. established CLIP (cross-linking and immunoprecipitation) for Argonaute proteins in Aedes aegypti. Their study sheds light on small RNA-target interactions in mosquitoes and provides an important resource for further study.

Keywords: Aedes aegypti; Argonaute; CLIP; RNAi; miRNA; siRNA.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Aedes* / genetics
Animals
RNA
RNA Interference

Substances

RNA