ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer

Affiliations

• ¹ Division of Hematology & Medical Oncology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA.
• ² Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
• ³ Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York University, New York, NY, USA.
• ⁴ Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.
• ⁵ Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• ⁶ Department of Radiation Oncology, Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY, USA.
• ⁷ Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
• ⁸ Department of Medicine, Harvard Medical School, Boston, MA, USA.
• ⁹ Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
• ¹⁰ Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
• ¹¹ Department of Medicine, Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY, USA.
• ¹² Department of Pathology, New York University School of Medicine, New York, NY, USA.
• ¹³ Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
• ¹⁴ Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• ¹⁵ Department of Chemical and Systems Biology, Chem-H and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA, USA.
• ¹⁶ Howard Hughes Medical Institute, New York University School of Medicine, New York, NY, USA.
• ¹⁷ Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
• ¹⁸ Division of Hematology & Medical Oncology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA. Kwok-Kin.Wong@nyulangone.org.