Reliability and agreement of proton density-weighted vs. gadolinium-enhanced T1-weighted MRI in hand osteoarthritis. An OMERACT MRI special interest group reliability exercise

Ø Maugesten; S J Pedersen; M S Stoenoiu; Fpb Kroon; A J Mathew; H K Genant; P G Conaghan; F Gandjbakhch; M Kloppenburg; C Peterfy; M Østergaard; I K Haugen

doi:10.1016/j.semarthrit.2021.05.007

Reliability and agreement of proton density-weighted vs. gadolinium-enhanced T1-weighted MRI in hand osteoarthritis. An OMERACT MRI special interest group reliability exercise

Semin Arthritis Rheum. 2021 Aug;51(4):929-932. doi: 10.1016/j.semarthrit.2021.05.007. Epub 2021 May 21.

Authors

Ø Maugesten¹, S J Pedersen², M S Stoenoiu³, Fpb Kroon⁴, A J Mathew⁵, H K Genant⁶, P G Conaghan⁷, F Gandjbakhch⁸, M Kloppenburg⁹, C Peterfy¹⁰, M Østergaard⁵, I K Haugen¹¹

Affiliations

¹ Division of Rheumatology and Research, Diakonhjemmet Hospital, Box 23 Vinderen, Oslo N-0319, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway. Electronic address: oystein.maugesten@gmail.com.
² Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark.
³ Department of Rheumatology, Cliniques Universitaires Saint Luc, Brussels, Belgium; Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Belgium.
⁴ Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands; Department of Rheumatology, Zuyderland Medical Center, Heerlen, the Netherlands.
⁵ Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen, Copenhagen, Denmark.
⁶ Department of radiology and biomedical imaging, University of California, San Francisco, United States.
⁷ Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds, UK.
⁸ Department of Rheumatology, Sorbonne University, APHP, Pitié-Salpêtrière Hospital, Paris, France.
⁹ Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.
¹⁰ Spire Sciences, Inc., Boca Raton, FL 33487, United States.
¹¹ Division of Rheumatology and Research, Diakonhjemmet Hospital, Box 23 Vinderen, Oslo N-0319, Norway.

PMID: 34140182
DOI: 10.1016/j.semarthrit.2021.05.007

Abstract

Objectives: To compare reliabilities of assessing synovitis in hand osteoarthritis (OA) using Magnetic Resonance Imaging (MRI) with/without gadolinium (Gd).

Methods: Three readers scored synovitis on non-enhanced two-dimensional (2D) proton density (PD)-weighted MRI and Gd-enhanced (3D) MRI of hand joints in 20 patients. Inter-reader reliabilities were examined.

Results: Reliability was good for Gd-enhanced MRI, but poor for non-enhanced PD-weighted MRI (intraclass correlation coefficient 0.83 and 0.21, respectively). Agreement between the two sequences was poor (weighted kappa 0.18).

Conclusion: Gd-enhanced MRI was more reliable than PD-weighted MRI for assessing synovitis. Gd-enhancement, but also resolution and tissue contrast, might have contributed to this.

Keywords: Hand; MRI; OMERACT; Osteoarthritis; Synovitis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Contrast Media
Gadolinium
Humans
Magnetic Resonance Imaging
Osteoarthritis* / diagnostic imaging
Protons
Public Opinion
Reproducibility of Results
Synovitis* / diagnostic imaging

Substances

Contrast Media
Protons
Gadolinium

Grants and funding

DH_/Department of Health/United Kingdom