Roles of Interferon Induced Protein with Tetratricopeptide Repeats (IFIT) Family in Cancer

Curr Med Chem. 2021;28(25):5034-5047. doi: 10.2174/0929867328666210617105209.

Abstract

The Interferon-induced protein with tetratricopeptide repeats (IFIT) family is an important component of the antiviral immune response. There are currently four known IFIT family members in humans, namely IFIT1, IFIT2, IFIT3 and IFIT5. Recent discoveries have brought attention to the significant roles of IFITs in cancer. This review summarises current knowledge on the biological roles of different IFIT proteins in various types of malignant neoplasm, and highlights the potential use of these molecules as cancer biomarkers and prognostic factors.

Keywords: Cancer; IFIT; biomarker; interferon-induced protein; prognostic factor.; tetratricopeptide repeats.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing* / physiology
  • Antiviral Agents
  • Apoptosis Regulatory Proteins* / physiology
  • Humans
  • Intracellular Signaling Peptides and Proteins* / physiology
  • Neoplasm Proteins* / physiology
  • Neoplasms* / drug therapy
  • Neoplasms* / genetics
  • Proteins
  • RNA-Binding Proteins* / physiology
  • Tetratricopeptide Repeat

Substances

  • Adaptor Proteins, Signal Transducing
  • Antiviral Agents
  • Apoptosis Regulatory Proteins
  • IFIT1 protein, human
  • IFIT2 protein, human
  • IFIT3 protein, human
  • IFIT5 protein, human
  • Intracellular Signaling Peptides and Proteins
  • Neoplasm Proteins
  • Proteins
  • RNA-Binding Proteins