Synthesis of Difluoroglycine Derivatives from Amines, Difluorocarbene, and CO2 : Computational Design, Scope, and Applications

Hiroki Hayashi; Hideaki Takano; Hitomi Katsuyama; Yu Harabuchi; Satoshi Maeda; Tsuyoshi Mita

doi:10.1002/chem.202101793

Synthesis of Difluoroglycine Derivatives from Amines, Difluorocarbene, and CO₂ : Computational Design, Scope, and Applications

Chemistry. 2021 Jul 12;27(39):9965-9966. doi: 10.1002/chem.202101793. Epub 2021 Jun 16.

Authors

Hiroki Hayashi^{1

2}, Hideaki Takano^{1

2}, Hitomi Katsuyama^{1

2}, Yu Harabuchi^{1

2

3}, Satoshi Maeda^{1

2

3

4}, Tsuyoshi Mita^{1

2}

Affiliations

¹ Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Kita 21 Nishi 10, Kita-ku, Sapporo, Hokkaido, 0010021, Japan.
² JST, ERATO Maeda Artificial Intelligence in Chemical Reaction, Design and Discovery Project, Kita 10 Nishi 8, Kita-ku, Sapporo, Hokkaido, 0600810, Japan.
³ Department of Chemistry, Faculty of Science, Hokkaido University, Kita 10 Nishi 8, Kita-ku, Sapporo, Hokkaido, 0600810, Japan.
⁴ Research and Services Division of Materials Data and Integrated System (MaDIS), National Institute for Materials Science (NIMS), Tsukuba, Ibaraki, 3050044, Japan.

PMID: 34132425
DOI: 10.1002/chem.202101793

Abstract

Invited for the cover of this issue are Satoshi Maeda, Tsuyoshi Mita, and co-workers at ICReDD (Hokkaido University). The image depicts an Artificial Force Induced Reaction (AFIR) conducted on a supercomputer, which predicts a new chemical transformation and its application. Read the full text of the article at 10.1002/chem.202100812.