Longitudinal changes in total and regional body composition in patients with chronic obstructive pulmonary disease

Felipe V C Machado; Martijn A Spruit; Miranda Coenjaerds; Fabio Pitta; Niki L Reynaert; Frits M E Franssen

doi:10.1111/resp.14100

Longitudinal changes in total and regional body composition in patients with chronic obstructive pulmonary disease

Respirology. 2021 Sep;26(9):851-860. doi: 10.1111/resp.14100. Epub 2021 Jun 15.

Authors

Felipe V C Machado^{1

2

3

4}, Martijn A Spruit^{1

2

3}, Miranda Coenjaerds⁵, Fabio Pitta⁴, Niki L Reynaert^{2

3}, Frits M E Franssen^{1

2

3}

Affiliations

¹ Department of Research and Development, Ciro - Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands.
² School of Nutrition and Translational Research in Metabolism, NUTRIM, Maastricht, The Netherlands.
³ Department of Respiratory Medicine, Maastricht University Medical Centre (MUMC+), Maastricht, The Netherlands.
⁴ Laboratory of Research in Respiratory Physiotherapy, Department of Physical Therapy, State University of Londrina, Londrina, Brazil.
⁵ Department of Dietetics, Ciro - Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands.

Abstract

Background and objective: Low fat-free mass (FFM) is common in patients with chronic obstructive pulmonary disease (COPD) and contributes to morbidity and mortality. Few studies have evaluated longitudinal changes in body composition in patients with COPD compared with non-COPD controls. This study aimed to compare longitudinal changes in total and regional body composition between patients with COPD and non-COPD controls and investigate predictors of changes in body composition in COPD.

Methods: Patients with COPD and non-COPD controls participating in the Individualized COPD Evaluation in relation to Ageing (ICE-Age) study, a single-centre, longitudinal, observational study, were included. Subjects were assessed at baseline and after 2 years of follow-up. Among other procedures, body composition was measured by dual-energy X-ray absorptiometry scan. The number of exacerbations/hospitalizations 1 year before inclusion and during follow-up were assessed in patients with COPD.

Results: A total of 405 subjects were included (205 COPD, 87 smoking and 113 non-smoking controls). Patients with COPD and smoking controls presented a significant decline in total FFM (mean [95% CI]: -1173 [-1527/-820] g and -486 [-816/-156] g, respectively) while body composition remained stable in non-smoking controls. In patients with COPD, the decline in FFM was more pronounced in legs (-174 [-361/14] g) and trunk (-675 [-944/406] g) rather than in arms (54 [-19/126] g). The predictors of changes in total and regional FFM in patients with COPD were gender, number of previous hospitalizations, baseline values of FFM and BMI.

Conclusion: Patients with COPD present a significant decline in FFM after 2 years of follow-up, this decline is more pronounced in their legs and trunk.

Keywords: body composition; chronic obstructive pulmonary disease; longitudinal change; low fat-free mass; physical activity; pulmonary rehabilitation.

Publication types

Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Absorptiometry, Photon
Aging
Body Composition*
Humans
Pulmonary Disease, Chronic Obstructive* / epidemiology