Ivacaftor-elexacaftor-tezacaftor and tacrolimus combination in cystic fibrosis

Abstract

The CFTR modulator combination elexacaftor/tezacaftor/ivacaftor (ETI) is a genetic mutation-targeted treatment in cystic fibrosis that results in profound improvements in clinical outcomes. Each of the compounds are substrates of CYP3A4/5, the cytochrome P450 enzyme family for which tacrolimus is also a substrate. The use of these compounds in an individual with a solid organ transplant has not been previously studied and there is potential for a drug interaction. In this report, we describe a pediatric liver transplant recipient with clinical decline related to cystic fibrosis who improved substantially with ETI, without significant impact on the systemic exposure of either ETI or tacrolimus.

Keywords: CFTR; Cytochrome p450; Drug interaction; Elexacaftor; Ivacaftor; Liver transplantation; Tacrolimus; Tezacaftor.