Chemical constituents from Tinospora sagittata and their biological activities

De-Feng Xu; Lei Miao; Yin-Yin Wang; Jun-Sheng Zhang; Hua Zhang

doi:10.1016/j.fitote.2021.104963

Chemical constituents from Tinospora sagittata and their biological activities

Fitoterapia. 2021 Sep:153:104963. doi: 10.1016/j.fitote.2021.104963. Epub 2021 Jun 12.

Authors

De-Feng Xu¹, Lei Miao¹, Yin-Yin Wang¹, Jun-Sheng Zhang¹, Hua Zhang²

Affiliations

¹ School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
² School of Biological Science and Technology, University of Jinan, Jinan 250022, China. Electronic address: bio_zhangh@ujn.edu.cn.

PMID: 34129922
DOI: 10.1016/j.fitote.2021.104963

Abstract

Six undescribed low-polarity compounds including three rare 14-methylergostane steroids (1-3), one euphane triterpenoid (4) and two octadecanoic acid ethyl esters (5 and 6), along with ten previously reported terpenyl cometabolites (7-16), were isolated from the stems of Tinospora sagittata. Their structures were determined by detailed spectroscopic analyses and comparison with structurally related known compounds, and all of them have been reported from T. sagittata for the first time. Compounds 4-6 and 16 showed potent in vitro inhibitory activity against the diabetes target α-glucosidase, while compounds 10 and 14 displayed promising antibacterial effect toward Staphylococcus aureus ATCC 25923.

Keywords: 14-methyl steroid; Antibacterial; Euphane triterpenoid; Inhibiting α-glucosidase; Tinospora sagittata.

MeSH terms

Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology*
China
Glycoside Hydrolase Inhibitors / isolation & purification
Glycoside Hydrolase Inhibitors / pharmacology*
Molecular Structure
Phytochemicals / isolation & purification
Phytochemicals / pharmacology
Plant Stems / chemistry
Staphylococcus aureus / drug effects
Tinospora / chemistry*

Substances

Anti-Bacterial Agents
Glycoside Hydrolase Inhibitors
Phytochemicals