Abstract
The effects of curcumin on the bioavailability of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) were investigated in Sprague-Dawley rats. Tetra- and penta-chlorinated PCDFs had the lowest bioavailability and hexa-chlorinated PCDD/Fs had the highest, while there was no obvious change in that of DL-PCBs. Curcumin markedly reduced the toxic equivalent (TEQ) of PCDD/Fs in rats, illustrating the potential to competitively inhibit absorption of PCDD/Fs by the epithelial cells of the small intestine due to the similar chemical structure (diphenyl) between curcumin and PCDD/Fs. Moreover, curcumin lowered the TEQ of DL-PCBs in the liver of male rats, but not female rats. The significant decrease in the bioavailability of PCDD/Fs and DL-PCBs demonstrates the potential detoxification mechanisms of curcumin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Animals
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Biological Availability
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Curcumin / administration & dosage*
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Dibenzofurans, Polychlorinated / administration & dosage
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Dibenzofurans, Polychlorinated / antagonists & inhibitors
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Dibenzofurans, Polychlorinated / pharmacokinetics*
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Dibenzofurans, Polychlorinated / toxicity
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Environmental Pollutants / administration & dosage
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Environmental Pollutants / antagonists & inhibitors
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Environmental Pollutants / pharmacokinetics*
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Environmental Pollutants / toxicity
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Female
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Intestinal Absorption / drug effects*
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Intestinal Mucosa / drug effects
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Intestinal Mucosa / metabolism
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Intestine, Small / drug effects
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Intestine, Small / metabolism
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Liver / drug effects
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Liver / metabolism
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Male
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Models, Animal
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Polychlorinated Dibenzodioxins / administration & dosage
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Polychlorinated Dibenzodioxins / antagonists & inhibitors
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Polychlorinated Dibenzodioxins / pharmacokinetics*
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Polychlorinated Dibenzodioxins / toxicity
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Rats
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Sex Factors
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Tissue Distribution / drug effects
Substances
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Dibenzofurans, Polychlorinated
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Environmental Pollutants
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Polychlorinated Dibenzodioxins
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Curcumin