Supercritical Fluid-Based Decellularization Technologies for Regenerative Medicine Applications

Beom-Seok Kim; Jeong-Uk Kim; Kyoung-Ha So; Nathaniel S Hwang

doi:10.1002/mabi.202100160

Supercritical Fluid-Based Decellularization Technologies for Regenerative Medicine Applications

Macromol Biosci. 2021 Aug;21(8):e2100160. doi: 10.1002/mabi.202100160. Epub 2021 Jun 13.

Authors

Beom-Seok Kim¹, Jeong-Uk Kim², Kyoung-Ha So², Nathaniel S Hwang^{1

2

3}

Affiliations

¹ Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, 08826, Republic of Korea.
² School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, 08826, Republic of Korea.
³ Bio-MAX Institute, Institute of Bio-Engineering, Seoul National University, Seoul, 08826, Republic of Korea.

PMID: 34121330
DOI: 10.1002/mabi.202100160

Abstract

Supercritical fluid-based extraction technologies are currently being increasingly utilized in high purity extract products for food industries. In recent years, supercritical fluid-based extraction technology is transformed in biomaterials process fields to be further utilized for tissue engineering and other biomedical applications. In particular, supercritical fluid-based decellularization protocols have great advantage over the conventional decellularization as it may allow preservation of extracellular matrix components and structures. In this review, the latest technological development utilizing the supercritical fluid-based decellularization for regenerative medicine is introduced.

Keywords: biomaterial; decellularization; regenerative medicine; supercritical fluid; tissue engineering.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biocompatible Materials
Extracellular Matrix* / chemistry
Regenerative Medicine* / methods
Technology
Tissue Engineering / methods
Tissue Scaffolds / chemistry

Substances

Biocompatible Materials