Prostaglandin E2, 9S-, 13S-HODE and resolvin D1 are strongly associated with the post-stroke cognitive impairment

Dariusz Kotlęga; Barbara Peda; Arleta Drozd; Agnieszka Zembroń-Łacny; Ewa Stachowska; Jarosław Gramacki; Małgorzata Szczuko

doi:10.1016/j.prostaglandins.2021.106576

Prostaglandin E2, 9S-, 13S-HODE and resolvin D1 are strongly associated with the post-stroke cognitive impairment

Prostaglandins Other Lipid Mediat. 2021 Oct:156:106576. doi: 10.1016/j.prostaglandins.2021.106576. Epub 2021 Jun 10.

Authors

Dariusz Kotlęga¹, Barbara Peda², Arleta Drozd³, Agnieszka Zembroń-Łacny⁴, Ewa Stachowska⁵, Jarosław Gramacki⁶, Małgorzata Szczuko⁷

Affiliations

¹ Department of Neurology, District Hospital, Glogow, Poland. Electronic address: dkotlega@uz.zgora.pl.
² Department of Neurology, District Hospital, Glogow, Poland. Electronic address: barbarapeda@op.pl.
³ Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, Poland. Electronic address: arleta.drozd@pum.edu.pl.
⁴ Department of Applied and Clinical Physiology, Collegium Medicum, University of Zielona Gora, Poland. Electronic address: a.zembron-lacny@cm.uz.zgora.pl.
⁵ Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, Poland. Electronic address: ewa.stachowska@pum.edu.pl.
⁶ Centre of Information Technologies, University of Zielona Gora, 65-417 Zielona Gora, Poland. Electronic address: j.gramacki@ck.uz.zgora.pl.
⁷ Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, Poland. Electronic address: malgorzata.szczuko@pum.edu.pl.

PMID: 34119645
DOI: 10.1016/j.prostaglandins.2021.106576

Abstract

Background: Inflammatory derivatives of free fatty acids are involved in the development of neuroinflammation and cognitive dysfunctions. The study aim was to establish the influence of eicosanoids on the cognitive status of stroke patients.

Methods: 73 stroke patients were prospectively evaluated towards the neuropsychological cognitive functions on the 7th day after stroke and after follow-up of 6 months. Eicosanoids levels were measured in all patients and compared to stroke-free controls (n = 30).

Results: Prostaglandin E2 was negatively correlated with Montreal Cognitive Assessment (MOCA) test on the 7th day after stroke. The level of 9-hydroxyoctadecadienoic acid (9S-HODE) was significantly higher in patients with cognitive dysfunctions in MOCA test compared to the others (group I mean ± SD: 0.040 ± 0.035 vs. group II: 0.0271 ± 0.016). In the initial neuropsychological assessment maresin 1-, 5-hydroxyeicosatetraenoic acid (HETE), 12S-HETE and 15S-HETE were negatively correlated with California Verbal Learning Test (CVLT) and thus with cognitive functions, while in the follow-up examination negative correlations were identified for prostaglandin E2, meresin 1, leukotriene B4, 13S HODE, 9S-HODE; the only positive correlation was observed in 15S-HETE. Other neuropsychological tests showed a beneficial impact of resolvin D1 and a negative role of prostaglandin E2 was observed in the first examination and in the follow-up. Resolvin D1 and the group of all analyzed eicosanoids predict changes in cognitive functions.

Conclusions: Eicosanoids can play a role in the neuroinflammation. They can affect the cognitive status at the stroke onset and have a predictive value for post-stroke cognitive decline. Prostaglandin E2, 9S-, 13S-HODE and resolvin D1 are the most important inflammatory free fatty acid derivatives in the cognitive functions in stroke. Eicosanoids predict post-stroke cognitive functions.

Keywords: Cerebrovascular diseases; Cognitive functions; Dementia; Eicosanoids; Inflammation; Inflammatory derivatives; Ischemic stroke; Lipids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dinoprostone*

Substances

Dinoprostone