Mechanisms and Practical Use of Biologic Therapies for Allergy and Asthma Indications

Cecelia Damask; Christine Franzese

doi:10.1016/j.otc.2021.04.003

Mechanisms and Practical Use of Biologic Therapies for Allergy and Asthma Indications

Otolaryngol Clin North Am. 2021 Aug;54(4):717-728. doi: 10.1016/j.otc.2021.04.003. Epub 2021 Jun 10.

Authors

Cecelia Damask¹, Christine Franzese²

Affiliations

¹ Lake Mary Ear, Nose, Throat, and Allergy, 795 Primera Boulevard, Suite 1031, Lake Mary, FL 32746, USA.
² Department of Otolaryngology-Head and Neck Surgery, University of Missouri-Columbia, One Hospital Drive, Suite MA314, Columbia, MO 65212, USA. Electronic address: franzesec@health.missouri.edu.

PMID: 34119334
DOI: 10.1016/j.otc.2021.04.003

Abstract

This article presents a concise overview of the important aspects of the immunologic mechanisms targeted by T-helper 2-directed monoclonal antibodies, as well as their practical applications in the treatment of allergic disorders (specifically allergic rhinitis) and asthma. Several of these novel agents treat multiple diseases, so understanding their targets and the underlying disease process can aid patient selection. In addition, the particular targets of the therapeutics seem to be shifting to include not only agents that intervene against inflammatory cytokines or their receptors but also specific molecular epitopes and cellular surface proteins.

Keywords: Allergic rhinitis; Anti-IgE; Anti-TSLP; Anti–IL-13; Anti–IL-4; Anti–IL-5; Asthma; Biologic agent.

Publication types

Review

MeSH terms

Antibodies, Monoclonal / therapeutic use
Asthma* / drug therapy
Biological Therapy
Humans
Rhinitis, Allergic* / drug therapy

Substances

Antibodies, Monoclonal