m6A modification of RNA and its role in cancer, with a special focus on lung cancer

Abstract

Epitranscriptomics involves functionally relevant biochemical modifications of RNA taking place at the transcriptome level without a change in the sequence of ribonucleotides. Several types of modifications that affect the processing and function of differentRNA types have been reported. Methylation at N₆ of Adenosine called m⁶A is one such modification, quite widespread in occurrence and reported in snRNAs, lncRNAs, circRNAs, rRNAs, miRNAs, and most abundantly, in mRNAs. The significant implications of m⁶A in various types of cancers are being widely recognized. Here, we give a brief about the enzymes that install the m⁶A modification (= m⁶A writers), that remove it (= m⁶A erasers) and certain RNA binding proteins (= m⁶A readers) which affect the fate of the m⁶A-containing RNA by recruiting various proteins. We also discuss the relevance of m⁶A in ncRNAs in various cancer types, followed by a discussion on the role of m⁶A of mRNA and ncRNA in lung cancer.

Keywords: Cancer; Circular RNA; lncRNAs; m6A; miRNAs.