Janus-Type Mesoporous Silica Nanoparticles for Sequential Tumoral Cell and Mitochondria Targeting

Methods Mol Biol. 2021:2275:341-361. doi: 10.1007/978-1-0716-1262-0_22.

Abstract

The development of nanoparticles has provided a powerful weapon in the fight against cancer due to the discovery of their selective accumulation in tumoral tissues, known as enhanced permeation and retention (EPR) effect (Peer et al, Nat Nanotechnol 2:751-760, 2007). Tumoral tissues require afastformation of blood vessels to sustain this rapid growth.

Keywords: Antitumoral therapy; Janus nanoparticles; Mitochondria targeting; Nanomedicine; Sequential targeting.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Drug Delivery Systems
  • Folate Receptors, GPI-Anchored / metabolism
  • Folic Acid / chemistry
  • Folic Acid / pharmacology*
  • Gene Expression Regulation, Neoplastic / drug effects
  • Humans
  • Male
  • Mice
  • Mitochondria / chemistry*
  • Nanoparticles
  • Organophosphorus Compounds / chemistry
  • Porosity
  • Prostatic Neoplasms / metabolism*
  • Silicon Dioxide / chemistry*

Substances

  • Folate Receptors, GPI-Anchored
  • Organophosphorus Compounds
  • triphenylphosphine
  • Silicon Dioxide
  • Folic Acid