Multi-Atlas MRI-Based Striatum Segmentation for 123I-FP-CIT SPECT (DAT-SPECT) Compared With the Bolt Method and SPECT-Atlas-Based Segmentation Method Toward the Accurate Diagnosis of Parkinson's Disease/Syndrome

Koji Sohara; Tetsuro Sekine; Amane Tateno; Sunao Mizumura; Masaya Suda; Takeshi Sakayori; Yoshiro Okubo; Shin-Ichiro Kumita

doi:10.3389/fmed.2021.662233

Multi-Atlas MRI-Based Striatum Segmentation for ¹²³I-FP-CIT SPECT (DAT-SPECT) Compared With the Bolt Method and SPECT-Atlas-Based Segmentation Method Toward the Accurate Diagnosis of Parkinson's Disease/Syndrome

Front Med (Lausanne). 2021 May 25:8:662233. doi: 10.3389/fmed.2021.662233. eCollection 2021.

Authors

Koji Sohara¹, Tetsuro Sekine², Amane Tateno³, Sunao Mizumura⁴, Masaya Suda¹, Takeshi Sakayori³, Yoshiro Okubo³, Shin-Ichiro Kumita¹

Affiliations

¹ Department of Radiology, Nippon Medical School Hospital, Tokyo, Japan.
² Department of Radiology, Nippon Medical School Musashi Kosugi Hospital, Kanagawa, Japan.
³ Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan.
⁴ Department of Radiology, Omori Medical Center, Toho University, Tokyo, Japan.

Abstract

Aims: This study aimed to analyze the performance of multi-atlas MRI-based parcellation for ¹²³I-FP-CIT SPECT (DAT-SPECT) in healthy volunteers. The proposed method was compared with the SPECT-atlas-based and Bolt methods. ¹⁸F-FE-PE2I-PET (DAT-PET) was used as a reference. Methods: Thirty healthy subjects underwent DAT-SPECT, DAT-PET, and 3D-T1WI-MRI. We calculated the striatum uptake ratio (SUR/SBR), caudate uptake ratio (CUR), and putamen uptake ratio (PUR) for DAT-SPECT using the multi-atlas MRI-based method, SPECT-atlas-based method, and Bolt method. In the multi-atlas MRI-based method, the cerebellum, occipital cortex, and whole-brain were used as reference regions. The correlation of age with DAT-SPECT activity and the correlations of SUR/SBR, CUR, and PUR between DAT-SPECT and DAT-PET were calculated by each of the three methods. Results: The correlation between age and SUR/SBR for DAT-SPECT based on the multi-atlas MRI-based method was comparable to that based on the SPECT-atlas-based method (r = -0.441 to -0.496 vs. -0.488). The highest correlation between DAT-SPECT and DAT-PET was observed using the multi-atlas MRI-based method with the occipital lobe defined as the reference region compared with the SPECT-atlas-based and Bolt methods (SUR, CUR, and PUR: 0.687, 0.723, and 0.676 vs. 0.698, 0.660, and 0.616 vs. 0.655). Conclusion: Multi-atlas MRI-based parcellation with the occipital lobe defined as the reference region was at least comparable to the clinical methods.

Keywords: 123I-FP-CIT; 18F-FE-PE2I; Bolt method; dopamine transporter; multi-atlas MRI based parcellation; positron emission tomography; semi-quantification; single photon emission computed tomography.