Echocardiographic Parameters Predict Short- and Long-Term Adverse Cardiovascular Events in Patients with Acute Myocardial Infarction

Meng-Meng Han; Wen-Shu Zhao; Xin Wang; Shan He; Xiao-Rong Xu; Cai-Jing Dang; Juan Zhang; Jia-Mei Liu; Mu-Lei Chen; Lin Xu; Hua Wang

doi:10.2147/IJGM.S304449

Echocardiographic Parameters Predict Short- and Long-Term Adverse Cardiovascular Events in Patients with Acute Myocardial Infarction

Int J Gen Med. 2021 Jun 3:14:2297-2303. doi: 10.2147/IJGM.S304449. eCollection 2021.

Authors

Meng-Meng Han^#¹, Wen-Shu Zhao^#², Xin Wang^#², Shan He³, Xiao-Rong Xu², Cai-Jing Dang², Juan Zhang², Jia-Mei Liu², Mu-Lei Chen², Lin Xu², Hua Wang²

Affiliations

¹ Intensive Care Units, Beijing Longfu Hospital, Beijing, 100010, People's Republic of China.
² Heart Center and Beijing Key Laboratory of Hypertension Research, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, People's Republic of China.
³ Heart Center, Beijing Chaoyang Hospital Jingxi Branch, Capital Medical University, Beijing, 100020, People's Republic of China.

^# Contributed equally.

Abstract

Objective: This study aimed to find echocardiographic parameters that can predict short- and long-term adverse cardiovascular events in patients with AMI.

Methods: A total of 126 patients with AMI admitted to our hospital from July to December 2012 were enrolled in this study. All patients underwent echocardiographic examination within 12 hours after admission and received regular follow-ups until December 2018. The primary endpoint was a composite of the major adverse cardiovascular events (MACEs).

Results: In the first year of this study, a primary endpoint occurred in 35 patients and the predictor derived from the echocardiography of 1-year primary endpoint was LVEF<40% (OR: 9.000, 95% CI 3.242-24.987, p<0.0001) and the area under the curve (AUC) for the predictor was 0.676 (95% CI 0.561-0.790, p=0.002). For the total 5 years, 57 patients underwent primary endpoint. The results of the 5-year primary endpoint were: E/E'>15 (OR: 4.094, 95% CI 1.726-9.710, P=0.001), the wall motion score index was (WMSI)>1.5 (OR: 12.791, 95% CI 1.511-108.312, P=0.019), and the AUC was 0.691 (95% CI 0.595-0.787 P<0.0001).

Conclusion: LVEF is correlated with a short-term outcome (1-year), and WMSI and E/E' can predict a long-term outcome (5-year) in patients with acute myocardial infarction.

Keywords: acute myocardial infarction; cardiovascular events; echocardiography; predictors; wall motion score index.

Grants and funding

This project was supported by the Atherosclerosis Special Fund Support Project of Chinese Medical Association (No. 09010390194) and the Basic and Clinical Research Cooperative project of Capital Medical University (No. 15JL04).