Polyprenylated acylphloroglucinol meroterpenoids with PTP1B inhibition from Hypericum forrestii

Fitoterapia. 2021 Sep:153:104959. doi: 10.1016/j.fitote.2021.104959. Epub 2021 Jun 7.

Abstract

Three new polyprenylated acylphloroglucinol meroterpenoids, hyperiforins A-C (1-3), were isolated from Hypericum forrestii (Chittenden) N. Robson, together with twelve known analogues (4-15). Their structures were established by extensive physical and spectroscopic data analysis. Compounds 1, 2, 5, 7, and 13-15 showed potent inhibitory effects on protein tyrosine phosphatase 1B with IC50 values from 6.63 ± 2.40 to 14.21 ± 3.51 μM.

Keywords: Acylphloroglucinol meroterpenoid; Clusiaceae; Hypericum forrestii (Chittenden) N. Robson; Hyperiforins A-C; Protein tyrosine phosphatase 1B.

MeSH terms

  • China
  • Hypericum / chemistry*
  • Molecular Structure
  • Phloroglucinol / isolation & purification
  • Phloroglucinol / pharmacology*
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Plant Components, Aerial / chemistry
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors*
  • Terpenes / isolation & purification
  • Terpenes / pharmacology*

Substances

  • Phytochemicals
  • Terpenes
  • Phloroglucinol
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1