Recent Approaches to Targeting Canonical NF κ B Signaling in the Early Inflammatory Response to Renal IRI

J Am Soc Nephrol. 2021 Sep;32(9):2117-2124. doi: 10.1681/ASN.2021010069. Epub 2021 Jun 9.

Abstract

Ischemia reperfusion injury (IRI) is the most common cause of in-hospital AKI and is associated with increased morbidity and mortality. IRI is associated with an early phase of inflammation primarily regulated by the canonical NFκB signaling pathway. Despite recent advances in our understanding of the pathogenesis of IRI, few therapeutic strategies have emerged. The purpose of this manuscript is to review interventions targeting NFκB after IRI.

Keywords: NF kappaB; inflammation; ischemia-reperfusion.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acute Kidney Injury / etiology*
  • Acute Kidney Injury / pathology
  • Acute Kidney Injury / therapy*
  • Humans
  • NF-kappa B / physiology*
  • Reperfusion Injury / etiology*
  • Reperfusion Injury / therapy*
  • Signal Transduction / physiology

Substances

  • NF-kappa B